bp(MESH:"Platelet Adhesiveness")
Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082
A remarkable rheological effect of RBCs that affects platelets in hemostasis and thrombosis is that RBCs preferentially move down the center of blood vessel, causing margination of platelets, so that they are poised to adhere preferentially to the site of vessel-wall injury [10]. PubMed:28458720
The hematocrit-related blood viscosity may have physical effects on the interaction between platelets and blood vessel surfaces.Under flow conditions, platelet adhesion increases greatly with hematocrit. PubMed:28458720
Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.