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a(CHEBI:"iron trichloride")

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Entity

Name
iron trichloride
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 14

a(HM:Thrombus) positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

bp(GO:"leukocyte adhesion to vascular endothelial cell") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

bp(MESH:"Lipid Peroxidation") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

FeCl3 treatment resulted in a dose- (Fig. 3) and timedependent (data not shown) increase inRBClipid peroxidation, which correlated closely with hemolysis (Fig. 2B). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

bp(MESH:"Platelet Adhesiveness") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

p(HGNC:HBB) positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Analysis of Hb release from ex vivo vessel chamber experiments revealed a significant (p  0.05; n  4) increase in Hb levels following FeCl3 treatment of isolated aorta in the presence of flowing blood (157  45 g/ml), whereas FeCl3 pretreatment of vessels prior to blood perfusion caused no hemolysis (Fig. 2A). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

p(HGNC:HBB) positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Analysis of the time course of hemolysis in whole blood revealed a rapid linear increase in Hb levels, peaking 10 min after FeCl3 addition (Fig. 2B), a time course consistent with the rapid hemolysis and vascular injury observed in the ex vivo aortic thrombosis model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) hasComponent a(CHEBI:"iron trichloride") View Subject | View Object

Appears in Networks:

path(HM:"Endothelial dysfunction") negativeCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

To investigate the direct effects of FeCl3 on aortic endothelium, FeCl3 was perfused through isolated aorta independently of flowing blood. Strikingly no endothelial denudation or collagen exposure was evident following prolonged exposure to FeCl3 (6%) (Fig. 1C). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Aorta
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

In contrast, selectively removing RBCs prevented endothelial denudation and collagen exposure, resulting in a relatively mild perturbation of endothelial function similar to that observed with FeCl3 alone (data not shown). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Introduction

path(MESH:"Vascular System Injuries") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

High concentrations of FeCl3 induce profound injury to the vasculature, leading to endothelial denudation, and collagen and tissue factor exposure, leading to the rapid formation of vaso-occlusive thrombi. PubMed:19276082

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Vascular System Injuries") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

As demonstrated in Fig. 1, topically exposing aorta in vivo (Fig. 1A) or ex vivo (Fig. 1B) to 6% FeCl3 resulted in major vascular injury as evidenced by endothelial denudation, collagen exposure, and the subsequent formation of arterial thrombi (Fig. 1D and supplemental Video 1). PubMed:19276082

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Vascular System Injuries") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Analysis of the time course of hemolysis in whole blood revealed a rapid linear increase in Hb levels, peaking 10 min after FeCl3 addition (Fig. 2B), a time course consistent with the rapid hemolysis and vascular injury observed in the ex vivo aortic thrombosis model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

path(MESH:Hemolysis) positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Analysis of the time course of hemolysis in whole blood revealed a rapid linear increase in Hb levels, peaking 10 min after FeCl3 addition (Fig. 2B), a time course consistent with the rapid hemolysis and vascular injury observed in the ex vivo aortic thrombosis model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

Out-Edges 13

a(CHEBI:"iron trichloride") positiveCorrelation path(MESH:"Vascular System Injuries") View Subject | View Object

High concentrations of FeCl3 induce profound injury to the vasculature, leading to endothelial denudation, and collagen and tissue factor exposure, leading to the rapid formation of vaso-occlusive thrombi. PubMed:19276082

Appears in Networks:
Annotations
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(MESH:"Vascular System Injuries") View Subject | View Object

As demonstrated in Fig. 1, topically exposing aorta in vivo (Fig. 1A) or ex vivo (Fig. 1B) to 6% FeCl3 resulted in major vascular injury as evidenced by endothelial denudation, collagen exposure, and the subsequent formation of arterial thrombi (Fig. 1D and supplemental Video 1). PubMed:19276082

Appears in Networks:
Annotations
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(MESH:"Vascular System Injuries") View Subject | View Object

Analysis of the time course of hemolysis in whole blood revealed a rapid linear increase in Hb levels, peaking 10 min after FeCl3 addition (Fig. 2B), a time course consistent with the rapid hemolysis and vascular injury observed in the ex vivo aortic thrombosis model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") negativeCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

To investigate the direct effects of FeCl3 on aortic endothelium, FeCl3 was perfused through isolated aorta independently of flowing blood. Strikingly no endothelial denudation or collagen exposure was evident following prolonged exposure to FeCl3 (6%) (Fig. 1C). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

In contrast, selectively removing RBCs prevented endothelial denudation and collagen exposure, resulting in a relatively mild perturbation of endothelial function similar to that observed with FeCl3 alone (data not shown). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation bp(GO:"leukocyte adhesion to vascular endothelial cell") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation bp(MESH:"Platelet Adhesiveness") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation p(HGNC:HBB) View Subject | View Object

Analysis of Hb release from ex vivo vessel chamber experiments revealed a significant (p  0.05; n  4) increase in Hb levels following FeCl3 treatment of isolated aorta in the presence of flowing blood (157  45 g/ml), whereas FeCl3 pretreatment of vessels prior to blood perfusion caused no hemolysis (Fig. 2A). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation p(HGNC:HBB) View Subject | View Object

Analysis of the time course of hemolysis in whole blood revealed a rapid linear increase in Hb levels, peaking 10 min after FeCl3 addition (Fig. 2B), a time course consistent with the rapid hemolysis and vascular injury observed in the ex vivo aortic thrombosis model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Analysis of the time course of hemolysis in whole blood revealed a rapid linear increase in Hb levels, peaking 10 min after FeCl3 addition (Fig. 2B), a time course consistent with the rapid hemolysis and vascular injury observed in the ex vivo aortic thrombosis model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation bp(MESH:"Lipid Peroxidation") View Subject | View Object

FeCl3 treatment resulted in a dose- (Fig. 3) and timedependent (data not shown) increase inRBClipid peroxidation, which correlated closely with hemolysis (Fig. 2B). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation a(HM:Thrombus) View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.