1. Catalog
  2. Nodes
  3. complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin))

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

path(HM:"Endothelial dysfunction") positiveCorrelation complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) View Subject | View Object

Topical treatment with 6% FeCl3 with hemin (1mM) perfusions caused no greater endothelial injury than FeCl3 or hemin (1 mM) alone (data not shown), whereas FeCl3 in the presence of low concentrations of metHb (0.38 mg/ml) induced extensive vascular injury similar to that observed with FeCl3 in the presence of whole blood (Figs. 4 and 1D, respectively). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) View Subject | View Object

Third, reintroduction of washed RBCs or purified metHb in the presence of FeCl3 led to a similar level of vascular injury as observed with whole blood, whereas isolated RBC membranes and heme, even in the presence of FeCl3, produced relatively mild injury. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Discussion

Out-Edges 4

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) hasComponent a(CHEBI:"iron trichloride") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) hasComponent a(CHEBI:methemoglobin) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

Topical treatment with 6% FeCl3 with hemin (1mM) perfusions caused no greater endothelial injury than FeCl3 or hemin (1 mM) alone (data not shown), whereas FeCl3 in the presence of low concentrations of metHb (0.38 mg/ml) induced extensive vascular injury similar to that observed with FeCl3 in the presence of whole blood (Figs. 4 and 1D, respectively). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

Third, reintroduction of washed RBCs or purified metHb in the presence of FeCl3 led to a similar level of vascular injury as observed with whole blood, whereas isolated RBC membranes and heme, even in the presence of FeCl3, produced relatively mild injury. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.