HBP00044

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: HBP00044
Namespace: HBP
Namespace Version: 20181029
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

In-Edges 2

p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044) View Subject | View Object

Interestingly, this ratio is also increased, but to a lesser extent, in tau-A152T neurons (Figure S3F) PubMed:27594586

Appears in Networks:

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Annotations

Confidence: Medium
MeSH: Cerebral Cortex
MeSH: Neurons
MeSH: Frontotemporal Dementia

g(DBSNP:rs63751011) decreases a(HBP:HBP00044) View Subject | View Object

As expected, the 4R/3R tau ratio is greatly increased in MAPT IVS10+16 neurons (Figure S3F) but not in GRN mutant neurons (Figure S3G) PubMed:27594586

Appears in Networks:

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Annotations

Confidence: Medium
MeSH: Cerebral Cortex
MeSH: Neurons
MeSH: Frontotemporal Dementia

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.