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Entity

Name
excitatory synapse
Namespace
go
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/go-names.belns

Appears in Networks 2

In-Edges 4

a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) View Subject | View Object

Additionally, NF-κB activity is also actuated by glutamate- mediated excitatory neurotransmission in the hippocampus, cerebral cortex, and the cerebellar granule cells PubMed:28745240

a(PUBCHEM:9832404) increases a(GO:"excitatory synapse") View Subject | View Object

Measurements of PSD95 for excitatory shaft synapse volumes (indicative of synaptic maturation) showed significant increases in Adnp+/– mice in both hippocampus and cortex (P < 0.05), but not in the male mouse cortical spines. We observed a further increase with NAP treatment in female mice only, suggesting a compensatory effect (Supplemental Figures 1 and 2, insets). PubMed:30106381

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") View Subject | View Object

Further sex comparisons revealed differences in excitatory synapse numbers, with the Adnp+/– male mice showing significantly reduced hippocampal spine density, coupled with increased immature pathologic excitatory shaft synapses compared with Adnp+/– female mice (P < 0.01, Supplemental Table 2) PubMed:30106381

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") View Subject | View Object

Measurements of PSD95 for excitatory shaft synapse volumes (indicative of synaptic maturation) showed significant increases in Adnp+/– mice in both hippocampus and cortex (P < 0.05), but not in the male mouse cortical spines. We observed a further increase with NAP treatment in female mice only, suggesting a compensatory effect (Supplemental Figures 1 and 2, insets). PubMed:30106381

Out-Edges 3

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Additionally, NF-κB activity is also actuated by glutamate- mediated excitatory neurotransmission in the hippocampus, cerebral cortex, and the cerebellar granule cells PubMed:28745240

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Consequently, NF-κB is constitutively activated in the excitatory neurons of the cerebral cortex (layers 2, 4, and 5), hippocampus (granule and pyramidal neurons of CA1 and CA3), and cerebellar granule cells and this constitutive activity is indispensable for neuronal survival in response to glutamate-induced excitotoxicity PubMed:28745240

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The molecular mechanism underlying constitutive activation of NF-κB by glutamate-induced excitatory synaptic neurotransmission has been ascribed to NMDA receptor mediated Ca2+ influx and subsequent activation of CaMKII PubMed:28745240

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.