a(GO:"excitatory synapse")
Additionally, NF-κB activity is also actuated by glutamate- mediated excitatory neurotransmission in the hippocampus, cerebral cortex, and the cerebellar granule cells PubMed:28745240
Measurements of PSD95 for excitatory shaft synapse volumes (indicative of synaptic maturation) showed significant increases in Adnp+/– mice in both hippocampus and cortex (P < 0.05), but not in the male mouse cortical spines. We observed a further increase with NAP treatment in female mice only, suggesting a compensatory effect (Supplemental Figures 1 and 2, insets). PubMed:30106381
Further sex comparisons revealed differences in excitatory synapse numbers, with the Adnp+/– male mice showing significantly reduced hippocampal spine density, coupled with increased immature pathologic excitatory shaft synapses compared with Adnp+/– female mice (P < 0.01, Supplemental Table 2) PubMed:30106381
Measurements of PSD95 for excitatory shaft synapse volumes (indicative of synaptic maturation) showed significant increases in Adnp+/– mice in both hippocampus and cortex (P < 0.05), but not in the male mouse cortical spines. We observed a further increase with NAP treatment in female mice only, suggesting a compensatory effect (Supplemental Figures 1 and 2, insets). PubMed:30106381
Additionally, NF-κB activity is also actuated by glutamate- mediated excitatory neurotransmission in the hippocampus, cerebral cortex, and the cerebellar granule cells PubMed:28745240
Consequently, NF-κB is constitutively activated in the excitatory neurons of the cerebral cortex (layers 2, 4, and 5), hippocampus (granule and pyramidal neurons of CA1 and CA3), and cerebellar granule cells and this constitutive activity is indispensable for neuronal survival in response to glutamate-induced excitotoxicity PubMed:28745240
The molecular mechanism underlying constitutive activation of NF-κB by glutamate-induced excitatory synaptic neurotransmission has been ascribed to NMDA receptor mediated Ca2+ influx and subsequent activation of CaMKII PubMed:28745240
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.