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p(MGI:Ftl1)

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Entity

Name
Ftl1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"desferrioxamine B") decreases p(MGI:Ftl1) View Subject | View Object

Expectedly, and in line with previous report (13), treatment of macrophages with DFO abolished ferroportin and ferritin induction by heme, whereas TfR1 expression was lowered upon heme and combined treatment with heme and DFO (Fig. 7D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:heme) increases p(MGI:Ftl1) View Subject | View Object

We also confirmed ferritin light chain enhancement as a common response to heme exposure of Hmox1 (+/+) and Hmox1 (−/ −) MEF cells (Figure 3a). PubMed:25301065

Appears in Networks:
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Text Location
Results

a(CHEBI:heme) increases p(MGI:Ftl1) View Subject | View Object

In a time-line experiment, we showed that heme loading of macrophages decreased the expression of heme–hemopexin complex receptor and transferrin receptor 1 (TfR1) (Fig. 4D), while ferritin levels remained largely unchanged except for an increase in ferritin levels at 16 h post-treatment (Fig. 4D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Ftl1) View Subject | View Object

As expected, serum ferritin was significantly increased in CEP mice (Figure 3H). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Ftl1) View Subject | View Object

Ferritin protein level was significantly increased in the cortex but not in the medulla of CEP mice, confirming exclusive iron handing in the proximal renal tubules in these mice (Figure 6B); no change in the mRNA-expression of ferritin was observed (Figure 6B). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

Out-Edges 2

p(MGI:Ftl1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

As expected, serum ferritin was significantly increased in CEP mice (Figure 3H). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

p(MGI:Ftl1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Ferritin protein level was significantly increased in the cortex but not in the medulla of CEP mice, confirming exclusive iron handing in the proximal renal tubules in these mice (Figure 6B); no change in the mRNA-expression of ferritin was observed (Figure 6B). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.