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a(HBP:HBP00092)

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Entity

Name
HBP00092
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 3

Alpha-synuclein oligomers: a new hope v1.0.0

Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

In-Edges 4

a(CHEBI:curcumin) decreases a(HBP:HBP00092) View Subject | View Object

In vitro studies have shown that curcumin inhibited the formation of fibrils and disaggregated amyloid-beta and a-syn [112, 114, 155]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum

a(HBP:HBP00093) increases a(HBP:HBP00092) View Subject | View Object

. Multiple lines of evidence now suggest that oligomeric species of a-syn, which are thought to precede the fibrillar aggregates found in Lewy bodies, are the culprits for neuronal degeneration in Parkinson’s disease PubMed:28803412

Appears in Networks:
Annotations
Confidence
Medium

a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092) View Subject | View Object

Increasing amounts of fibrils and a concomitant decrease in the amount of oligomeric species were observed upon longer incubation times (Supplementary Fig. S1). PubMed:27075649

Appears in Networks:
Annotations
MeSH
Intracellular Space
Cell Ontology (CL)
neuron
Confidence
Medium
MeSH
Lewy Bodies

p(HGNC:IDE) decreases a(HBP:HBP00092) View Subject | View Object

IDE also degrades and prevents the forma- tion of α-synuclein fibrils 259 . PubMed:30116051

Appears in Networks:

Out-Edges 7

a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process") View Subject | View Object

In contrast, a-syn 30–110 that forms fibrils at a fast rate, did not display toxicity, indicating that oligomers are indeed the toxic species leading to TH-neuron loss in vivo [162]. PubMed:28803412

Appears in Networks:
Annotations
Cell Ontology (CL)
neuron
Confidence
High

a(HBP:HBP00092) increases bp(GO:"inflammatory response") View Subject | View Object

a report by Hoffmann et al. showed that fibrillar a-syn induced a more pronounced inflammatory response in microglial cells [61]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Microglia

a(HBP:HBP00092) increases bp(GO:"microglial cell activation") View Subject | View Object

a report by Hoffmann et al. showed that fibrillar a-syn induced a more pronounced inflammatory response in microglial cells [61]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Microglia

a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)") View Subject | View Object

1 nM (Fig. 3a, right panels and Fig. 3b, red curve, solid line) and 0.2 nM α -syn fibrils (Fig. 3b, red curve, dashed line) induced a progressive and significant increase of intracellular Ca2+ levels, as revealed by the rise of Fluo-4 fluorescence in exposed SH-SY5Y cells. In contrast, only a modest Ca2+ increase was observed in cells exposed to 300 nM on-fibrillar assembly pathway oligomeric α -syn (Fig. 3a, middle panels and Fig. 3b, blue curve, solid line) or 10 μM monomeric α -syn (Fig. 3a, left panels and Fig. 3b, black curve, solid line). PubMed:27075649

Appears in Networks:
Annotations
MeSH
Intracellular Space
Cell Ontology (CL)
neuron
Confidence
Medium
MeSH
Lewy Bodies

a(HBP:HBP00092) increases bp(GO:"apoptotic process") View Subject | View Object

α -syn fibrils revealed to be highly toxic to cells at all the concentrations we tested, spanning 1 to 0.01 nM (53.4 ± 4% inhibition of MTT reduction at 0.01 nM, i.e. 0.1 μM equivalent monomer concentration) whereas α -syn oligomers only slightly impaired cell viability (23.9 ± 6% inhibition of MTT reduction at 300 nM, i.e. 10 μM initial monomer concentration) (Fig. 3c). PubMed:27075649

Appears in Networks:
Annotations
MeSH
Intracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Lewy Bodies

a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093) View Subject | View Object

Increasing amounts of fibrils and a concomitant decrease in the amount of oligomeric species were observed upon longer incubation times (Supplementary Fig. S1). PubMed:27075649

Appears in Networks:
Annotations
MeSH
Intracellular Space
Cell Ontology (CL)
neuron
Confidence
Medium
MeSH
Lewy Bodies

a(HBP:HBP00092) increases a(HBP:HBP00016) View Subject | View Object

The high proportion of cells with overlapping ChFP and ATTO-488 puncta (89 ± 7% upon cell exposure to 0.06 nM ATTO-488-labeled α -syn fibrils, Fig. 6f) indicates that α -syn fibrils seed with high efficiency the aggregation of soluble cytoplasmic ChFP-α -syn. PubMed:27075649

Appears in Networks:
Annotations
MeSH
Intracellular Space
Cell Ontology (CL)
neuron
Confidence
Low
MeSH
Lewy Bodies

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.