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p(HGNC:SYP)

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Entity

Name
SYP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 4

bp(GO:memory) association p(HGNC:SYP) View Subject | View Object

In fact, the memory deficit and neuropathology severity observed in patients exhibiting AD highly correlate with changes in hippocampal synaptic transmission, especially with changes in synaptophysin expression, a presynaptic vesicle protein PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(HGNC:SQSTM1) increases p(HGNC:SYP) View Subject | View Object

For example, Babu et al. has shown that p62−/− knockout mice have increased levels of hyperphosphorylated tau, reduction of synaptophysin and changes in short term memory compared to p62+/− [54] PubMed:29758300

Appears in Networks:

p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) View Subject | View Object

We also looked at the presynaptic protein synaptophysin, which was not significantly altered in TauRDΔK oligomer-treated cells compared with buffer- or monomer-treated cells (Fig 4D, bar 12). However, at higher concentration, synaptophysin tends to be reduced. PubMed:28528849

Appears in Networks:

complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) hasComponent p(HGNC:SYP) View Subject | View Object

Appears in Networks:

Out-Edges 2

p(HGNC:SYP) association bp(GO:memory) View Subject | View Object

In fact, the memory deficit and neuropathology severity observed in patients exhibiting AD highly correlate with changes in hippocampal synaptic transmission, especially with changes in synaptophysin expression, a presynaptic vesicle protein PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) View Subject | View Object

Multiple studies have demonstrated the presence of NF-κB in the synapses and synaptosomal preparations [25, 35, 39] and the presynaptic protein synaptophysin has been shown to co-localize with the p65 and p50 subunits of NF- κB in synaptosomal preparations [25, 35, 39], also been observed in the dendritic spines of the post-synaptic densities of the synaptosomes isolated from the hippocampus and the cerebral cortex PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.