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bp(GO:"phosphatidylinositol 3-kinase signaling")

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Entity

Name
phosphatidylinositol 3-kinase signaling
Namespace
go
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73688d6dc24e309fca59a1340dc9ee971e9f3baa/external/go-names.belns

Appears in Networks 3

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 1

act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") View Subject | View Object

Mechanistically, nicotine, acting through nAChRs, decreases keratinocyte migration (188, 189) and modifies the activity of PI3K/Akt, ERK, MEK, and JAK signaling pathways. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Keratinocytes
Text Location
Review

Out-Edges 4

bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

In cell lines, this interaction of trans-activating components is also under the regulation of the Ras-dependent MAPK and pathways related to phosphoinositide-3-kinase (PI3K) and MEK activation whose response to trophic factors such as nerve growth factor (NGF) contributes to regulating transcript initiation. PubMed:19126755

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Annotations
Text Location
Review

bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") View Subject | View Object

Recent studies have also demonstrated the importance of the phos- phatidylinositol 3-kinase (PI3K) pathway downstream of AChRs in pro- tecting neurons from death and up-regulating these receptors [148]. PubMed:22040696

Appears in Networks:

bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) View Subject | View Object

Recent studies have also demonstrated the importance of the phos- phatidylinositol 3-kinase (PI3K) pathway downstream of AChRs in pro- tecting neurons from death and up-regulating these receptors [148]. PubMed:22040696

Appears in Networks:

bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Several kinase pathways including the calcium-calmodium dependent kinase-II (CaMK), the protein kinases-C (PKC) and the ras/phosphatidylinositol 3-kinase (PI3K) pathways have been implicated in activating neuronal NF-κB signaling PubMed:25652642

Appears in Networks:
Annotations
MeSH
Neurons

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.