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Appears in Networks 3

In-Edges 8

complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14) PubMed:28019679

act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) View Subject | View Object

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14) PubMed:28019679

act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) View Subject | View Object

In addition, inflammasome activation causes a rapid, proinflammatory form of cell death called pyroptosis4. PubMed:23702978

complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

p(HGNC:SCAF11) increases bp(GO:pyroptosis) View Subject | View Object

Pyroptosis in response to live Gram-negative bacteria but not in response to other inflammasome triggers is entirely dependent on caspase 11, whereas caspase 1 is dispensable for this process41 PubMed:23702978

act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis. PubMed:27314526

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.