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p(HGNC:SCAF11)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SCAF11
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Activation and regulation of the inflammasomes v1.0.0

In-Edges 6

bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) View Subject | View Object

One checkpoint is that bacterial mRNA from live bacteria (also known as vita-PAMPs)44 activates NLRP3; the other checkpoint is that TLR4- and TRIF (TIR domain-containing adaptor protein inducing IFNβ)-dependent signalling — which is triggered by bacterial lipopolysaccharide (LPS) — mediate the secretion of type I IFNs, inducing pro-caspase 11 expression and activation by triggering the IFNα/β receptor (IFNAR) (FIG. 1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interferon signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
XIAP subgraph

complex(p(HGNC:CFL1), p(HGNC:SCAF11)) hasComponent p(HGNC:SCAF11) View Subject | View Object

Appears in Networks:

act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) View Subject | View Object

One checkpoint is that bacterial mRNA from live bacteria (also known as vita-PAMPs)44 activates NLRP3; the other checkpoint is that TLR4- and TRIF (TIR domain-containing adaptor protein inducing IFNβ)-dependent signalling — which is triggered by bacterial lipopolysaccharide (LPS) — mediate the secretion of type I IFNs, inducing pro-caspase 11 expression and activation by triggering the IFNα/β receptor (IFNAR) (FIG. 1). PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interferon signaling subgraph

p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) View Subject | View Object

Even if the expression of pro-caspase 11 could be induced independently of IFN signalling, caspase 11 activation in macrophages in response to Salmonella enterica subsp. enterica serovar Typhimurium infection is dependent on IFNAR1 as well as signal tranducer and activator of transcription 1 (STAT1)46. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interferon signaling subgraph

act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) View Subject | View Object

Even if the expression of pro-caspase 11 could be induced independently of IFN signalling, caspase 11 activation in macrophages in response to Salmonella enterica subsp. enterica serovar Typhimurium infection is dependent on IFNAR1 as well as signal tranducer and activator of transcription 1 (STAT1)46. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interferon signaling subgraph

Out-Edges 2

p(HGNC:SCAF11) increases bp(GO:pyroptosis) View Subject | View Object

Pyroptosis in response to live Gram-negative bacteria but not in response to other inflammasome triggers is entirely dependent on caspase 11, whereas caspase 1 is dispensable for this process41 PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph

act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
XIAP subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.