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p(MGI:Tfrc)

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Entity

Name
Tfrc
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:heme) decreases p(MGI:Tfrc) View Subject | View Object

In a time-line experiment, we showed that heme loading of macrophages decreased the expression of heme–hemopexin complex receptor and transferrin receptor 1 (TfR1) (Fig. 4D), while ferritin levels remained largely unchanged except for an increase in ferritin levels at 16 h post-treatment (Fig. 4D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

complex(a(CHEBI:"desferrioxamine B"), a(CHEBI:heme)) decreases p(MGI:Tfrc) View Subject | View Object

Expectedly, and in line with previous report (13), treatment of macrophages with DFO abolished ferroportin and ferritin induction by heme, whereas TfR1 expression was lowered upon heme and combined treatment with heme and DFO (Fig. 7D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

p(MGI:Hpx) increases p(MGI:Tfrc) View Subject | View Object

Moreover, in CMs the heme-mediated induction of the iron exporter Ferroportin (Fpn) was abrogated by Hx treatment while the down-regulation of the iron importer Transferrin receptor 1 (TfR1) was significantly reduced by Hx (see Figure 3 in [37]) further indicating that Hx limits heme-iron accumulation within the cell. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

p(MGI:Hpx) increases p(MGI:Tfrc) View Subject | View Object

Moreover, the mRNA levels of Fpn and Flvcr1a were increased in Hx-/- mice, whereas those of the iron importers Divalent Metal Transporter 1 (Dmt1) and Tfr1 were decreased (see Figure 4 in [37]). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Tfrc) View Subject | View Object

However, the mRNA and protein expression of both TFR1 and DMT1 responsible for iron entry into renal cells were slightly decreased, although not reaching statistical significance (Online Supplementary Figure S4). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

Out-Edges 1

p(MGI:Tfrc) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

However, the mRNA and protein expression of both TFR1 and DMT1 responsible for iron entry into renal cells were slightly decreased, although not reaching statistical significance (Online Supplementary Figure S4). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.