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p(HGNC:AIF1)

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Entity

Name
AIF1
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/hgnc-names.belns

Appears in Networks 2

Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0

In-Edges 5

a(CHEBI:"amyloid-beta") increases p(HGNC:AIF1) View Subject | View Object

A significant increase in Iba-1 bur- den was observed in the cortex and hippocampus of Tg PS1/APPswe mice compared to their control wild-type littermates, suggesting increased Iba-1 immunopositive microglia in the brain of Tg PS1/APPswe mice (Fig 5A). PubMed:26010758

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases p(HGNC:AIF1) View Subject | View Object

Interestingly, Tg PS1/APPswe mice treated with anata- bine at a dosage of 20 mg/Kg/Day, but not 10mg/Kg/day showed a significant reduction in Iba- 1 burden in the hippocampus compared to untreated Tg PS1/APPswe mice (Fig 5A and 5B), suggesting that anatabine suppresses microgliosis in the brain of Tg PS1/APPswe mice. PubMed:26010758

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1) View Subject | View Object

A significant increase in Iba-1 bur- den was observed in the cortex and hippocampus of Tg PS1/APPswe mice compared to their control wild-type littermates, suggesting increased Iba-1 immunopositive microglia in the brain of Tg PS1/APPswe mice (Fig 5A). PubMed:26010758

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

a(PUBCHEM:9832404) decreases p(HGNC:AIF1) View Subject | View Object

In female mice, Akt1 (above) and ionized calcium–binding adapter molecule 1 (Iba1), a marker of microglial activation that crosslinks actin (42), were markedly increased in the Adnp+/– mouse spleen and normalized by NAP treatment, suggesting a potential peripheral inflammation–linked biomarker PubMed:30106381

Appears in Networks:
Annotations
MeSH
Spleen
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1) View Subject | View Object

In female mice, Akt1 (above) and ionized calcium–binding adapter molecule 1 (Iba1), a marker of microglial activation that crosslinks actin (42), were markedly increased in the Adnp+/– mouse spleen and normalized by NAP treatment, suggesting a potential peripheral inflammation–linked biomarker PubMed:30106381

Appears in Networks:
Annotations
MeSH
Spleen
Gender
Female

Out-Edges 1

p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation") View Subject | View Object

A significant increase in Iba-1 bur- den was observed in the cortex and hippocampus of Tg PS1/APPswe mice compared to their control wild-type littermates, suggesting increased Iba-1 immunopositive microglia in the brain of Tg PS1/APPswe mice (Fig 5A). PubMed:26010758

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.