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p(HGNC:MAPT, frag("?"))

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Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 5

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Tau in physiology and pathology v1.0.0

In-Edges 11

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, frag("?")) View Subject | View Object

Appears in Networks:

p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) View Subject | View Object

In addition to decreased degradation, one consequence is leakage of asparaginyl endopeptidase into the cytosol, where it generates toxic fragments of tau 61 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Cytosol
MeSH
Alzheimer Disease

a(MESH:"3-methyladenine") increases p(HGNC:MAPT, frag("?")) View Subject | View Object

Overexpressing only the repeat domain of tau containing an FTDP-17 mutation in neuroblastoma cells leads to tau aggregation as well as the appearance of smaller proteolytic fragments. Using the autophagy inhibitor 3-methyladenine (3-MA) to block the formation of autophagosomes led to an increase in both soluble and insoluble tau (94). PubMed:24027553

Appears in Networks:
Annotations
MeSH
Frontotemporal Dementia
Text Location
Review

bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) View Subject | View Object

On the other hand, it brings about tau fragmentation into pro-aggregating forms due to the failure of F1 to enter the lysosome PubMed:29626319

Appears in Networks:

p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) View Subject | View Object

However, there was a study indicating that calpain-mediated tau cleavage can result in the generation of tau fragments, which may possess neurotoxicity in AD (Ferreira and Bigio 2011) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) View Subject | View Object

Incomplete charperone-mediated autophagy of tau generates fragments that aggregate and are cleared by macroautophagy (Wang et al. 2009). PubMed:22908190

Appears in Networks:

deg(p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) View Subject | View Object

Incomplete charperone-mediated autophagy of tau generates fragments that aggregate and are cleared by macroautophagy (Wang et al. 2009). PubMed:22908190

Appears in Networks:

p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) View Subject | View Object

For instance, the phosphorylation of tau at Ser422 inhibits the cleavage of tau by caspase 3 at Asp421 PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases p(HGNC:MAPT, frag("?")) View Subject | View Object

For instance, the phosphorylation of tau at Ser422 inhibits the cleavage of tau by caspase 3 at Asp421 PubMed:26631930

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?")) View Subject | View Object

The truncation of tau occurs in AD and in other tauopathies PubMed:26631930

Appears in Networks:

path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) View Subject | View Object

The truncation of tau occurs in AD and in other tauopathies PubMed:26631930

Appears in Networks:

Out-Edges 6

p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") View Subject | View Object

Finally, while physiological tau possesses KFERQ motifs and is degraded by CMA, aggregates, mutant forms and frag- ments interfere with CMA 45,47 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) View Subject | View Object

However, there was a study indicating that calpain-mediated tau cleavage can result in the generation of tau fragments, which may possess neurotoxicity in AD (Ferreira and Bigio 2011) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, frag("?")) increases path(HBP:Neurodegeneration) View Subject | View Object

In addition, the truncation of tau may result in tau fragments that induce neurodegeneration independently of tau aggregation. PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") View Subject | View Object

Truncation of tau prevents the formation of this structure and might thereby promote tau aggregation PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") View Subject | View Object

Truncation of tau could generate tau fragments with a higher tendency for aggregation (see below), probably owing to the disruption of the paperclip structure of tau, as described above. PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") View Subject | View Object

Truncated tau fragments that contain the repeat domain have a higher tendency for aggregation, probably owing to the disruption of the usual paperclip structure PubMed:26631930

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.