bp(GO:"lysosomal microautophagy")
Selenium deficits have been linked to AD, and thus it is interesting that seleno- methionine boosted ALN flux, from AMPK recruit- ment through autophagosome formation to lysosomal degradation, in the 3×Tg AD mouse model 112 . PubMed:30116051
And autophagy-lysosomal activity is induced via two signal pathways: mammalian target of rapamycin (mTOR)-dependent pathway and mTORindependent pathway (Tan et al. 2014b) PubMed:29626319
However, their dysfunction in AD due to some factors will reduce Aβ clearance PubMed:29626319
Intracellular protein degradation is performed by UPS and ALS (Wong and Cuervo 2010 PubMed:29626319
Intracellular Aβ clearance can be achieved through UPS and ALS, and extracellular Aβ is degraded by glial phagocytosis, such as microglia, astrocytes, and proteases from neurons and astrocytes (Fig. 2) PubMed:29626319
Intracellular Aβ degradation pathways mainly contain two major pathways: UPS and ALS (Vilchez et al. 2014) PubMed:29626319
In addition, there is accumulating evidence to prove that Aβ can be cleared by ALS. PubMed:29626319
On the one hand, it is beneficial to the clearance of tau aggregates PubMed:29626319
On the other hand, it brings about tau fragmentation into pro-aggregating forms due to the failure of F1 to enter the lysosome PubMed:29626319
Microautophagy involves the nonselective entry of small quantities of cytoplasm into lysosomes or late endosomes/MVBs when the limiting membranes of these compartments invaginate and pinch off small vesicles for digestion within the lumen (Sahu et al. 2011). PubMed:22908190
Microautophagy involves the nonselective entry of small quantities of cytoplasm into lysosomes or late endosomes/MVBs when the limiting membranes of these compartments invaginate and pinch off small vesicles for digestion within the lumen (Sahu et al. 2011). PubMed:22908190
Microautophagy consists of direct engulfment of small volumes of cytosol by lysosomes [10], whereas chaperone-mediated autophagy (CMA) involves selective, receptor-mediated translocation of proteins into the lysosomal lumen [11]. PubMed:18930136
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