p(HGNC:SORL1)
Identified as a candidate susceptibility gene for AD by GWAS [116], reduced level of SORL1 has been consistently correlated with brain Aβ levels [118,119]. PubMed:29758300
One intriguing molecule that interacts with VPS35 is SORL1, a VPS10P-domain receptor protein that has been linked to autosomal dominant early-onset AD [116,117]. PubMed:29758300
Finally, the type I transmembrane protein SorLA/LR11 (a member of the VPS10p domain receptor fam- ily), which functionally interacts with cytosolic adaptors GGA and PACS-1, attenuates Aβ production by acting as a Golgi/ TGN retention factor (22). PubMed:18650430
Recently it was found that SorLA/ LR11 overexpression redistributed APP to the Golgi, decreasing Abeta generation, while SorLA/LR11 knockout mice have increased levels of Abeta, as found in AD patients [182] PubMed:21214928
One intriguing molecule that interacts with VPS35 is SORL1, a VPS10P-domain receptor protein that has been linked to autosomal dominant early-onset AD [116,117]. PubMed:29758300
Identified as a candidate susceptibility gene for AD by GWAS [116], reduced level of SORL1 has been consistently correlated with brain Aβ levels [118,119]. PubMed:29758300
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.