1. Catalog
  2. Nodes
  3. composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin))

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

In-Edges 0

Out-Edges 16

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) hasComponent a(CHEBI:"dasatinib (anhydrous)") View Subject | View Object

Appears in Networks:

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) hasComponent a(CHEBI:quercetin) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") View Subject | View Object

Consistent with senescent cell removal, intermittent DQ treatment significantly reduced the number of NFT-containing cortical neurons (P < 0.0001, 5% reduction; Figure 5a,b) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") View Subject | View Object

The DQ-dependent reduction in cortical NFTs corresponded with decreased ventricular volume pathology (28% decrease, P = 0.05, Figure 5d, f) and a reduction in cortical brain atrophy (compared to controls: P = 0.0092 and P = 0.0274, vehicle and DQ, respectively; Figure S5a) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") View Subject | View Object

The astrocyte protein GFAP was unchanged, while microglia Iba1 expression was elevated (Iba1: 40%, P = 0.0013; Figure S6b-d) suggesting that DQ-mediated neuroprotection and decreased SASP was not derived from a reduction in pro-inflammatory glia (astrocytes or microglia) but instead associated with fewer NFT-containing neurons PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") View Subject | View Object

Relative to the existing neuronal population at this advanced age, gene expression of the NFT-associated senescence gene array was reduced by DQ (P = 0.0006; Figure S6a) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") View Subject | View Object

The astrocyte protein GFAP was unchanged, while microglia Iba1 expression was elevated (Iba1: 40%, P = 0.0013; Figure S6b-d) suggesting that DQ-mediated neuroprotection and decreased SASP was not derived from a reduction in pro-inflammatory glia (astrocytes or microglia) but instead associated with fewer NFT-containing neurons PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") View Subject | View Object

The DQ-dependent reduction in cortical NFTs corresponded with decreased ventricular volume pathology (28% decrease, P = 0.05, Figure 5d, f) and a reduction in cortical brain atrophy (compared to controls: P = 0.0092 and P = 0.0274, vehicle and DQ, respectively; Figure S5a) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") View Subject | View Object

The DQ-dependent reduction in cortical NFTs corresponded with decreased ventricular volume pathology (28% decrease, P = 0.05, Figure 5d, f) and a reduction in cortical brain atrophy (compared to controls: P = 0.0092 and P = 0.0274, vehicle and DQ, respectively; Figure S5a) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") View Subject | View Object

However, tauNFT-Mapt0/0 mice treated with DQ did not display WMH volumes statistically different than control mice (P = 0.2458; Figure S5b, c) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

DQ improved cerebral blood flow in tauNFT Mapt0/0 mice such that cerebral blood flow was no longer statistically different from controls (Figure S5d, e) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Tauopathies

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) View Subject | View Object

DQ-treated mice expressed significantly higher levels of neuronal proteins (NeuN: 25%, synaptophysin: 40.8%; PSD95: 38.5%; P < 0.05; Figure 5f-i) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) View Subject | View Object

DQ-treated mice expressed significantly higher levels of neuronal proteins (NeuN: 25%, synaptophysin: 40.8%; PSD95: 38.5%; P < 0.05; Figure 5f-i) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) View Subject | View Object

DQ-treated mice expressed significantly higher levels of neuronal proteins (NeuN: 25%, synaptophysin: 40.8%; PSD95: 38.5%; P < 0.05; Figure 5f-i) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) View Subject | View Object

The astrocyte protein GFAP was unchanged, while microglia Iba1 expression was elevated (Iba1: 40%, P = 0.0013; Figure S6b-d) suggesting that DQ-mediated neuroprotection and decreased SASP was not derived from a reduction in pro-inflammatory glia (astrocytes or microglia) but instead associated with fewer NFT-containing neurons PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) View Subject | View Object

The astrocyte protein GFAP was unchanged, while microglia Iba1 expression was elevated (Iba1: 40%, P = 0.0013; Figure S6b-d) suggesting that DQ-mediated neuroprotection and decreased SASP was not derived from a reduction in pro-inflammatory glia (astrocytes or microglia) but instead associated with fewer NFT-containing neurons PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.