1. Catalog
  2. Nodes
  3. a(MESH:Mitochondria)

a(MESH:Mitochondria)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Mitochondria
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 3

Alpha-synuclein oligomers: a new hope v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

PP2A and Alzheimer Disease v1.0.0

In-Edges 3

a(HBP:HBP00093) decreases a(MESH:Mitochondria) View Subject | View Object

In 2014 Plotegher et al. showed that mitochondrial morphology is disrupted by a-syn oligomers, which cause fragmentation of these organelles in vitro in SH-SY5Y cells [124]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High

bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) View Subject | View Object

Citrate synthase activity is a surrogate marker of total mitochondrial content/mass, and was similar across genotypes and brain regions (Figure 3i) suggesting that the defects in cellular respiration were due to altered mitochondrial quality, not content/mass PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(FPLX:PPP2) association a(MESH:Mitochondria) View Subject | View Object

PP2A is mainly pre- sent as a soluble protein in the cytosol but it is also encoun- tered in the nucleus, mitochondria, cytoskeleton, and mem- branes. PubMed:22299660

Appears in Networks:

Out-Edges 2

a(MESH:Mitochondria) association p(FPLX:PPP2) View Subject | View Object

PP2A is mainly pre- sent as a soluble protein in the cytosol but it is also encoun- tered in the nucleus, mitochondria, cytoskeleton, and mem- branes. PubMed:22299660

Appears in Networks:

act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") View Subject | View Object

Citrate synthase activity is a surrogate marker of total mitochondrial content/mass, and was similar across genotypes and brain regions (Figure 3i) suggesting that the defects in cellular respiration were due to altered mitochondrial quality, not content/mass PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.