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a(CHEBI:"amyloid fibril")

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Entity

Name
amyloid fibril
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

In-Edges 2

a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril") View Subject | View Object

In addition, the load of AβO deposits significantly correlated with fibrillar Aβ plaque deposition as well as with neuronal loss and numbers of astrocytes, although not with memory deficits. PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High

p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") View Subject | View Object

Moreover, PrPC inhibits formation fibrillary form of Aβ, trapping Aβ in an oligomeric state (Younan et al. 2013). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Hippocampus

Out-Edges 2

a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) View Subject | View Object

It was also demonstrated that fibril-free AβO solutions are essential for memory loss (Brito-Moreira et al. 2017), while the fibrillar Aβ in amyloid deposits is not the active factor affecting the cognition (Martins et al. 2008). PubMed:29196815

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074) View Subject | View Object

In addition, the load of AβO deposits significantly correlated with fibrillar Aβ plaque deposition as well as with neuronal loss and numbers of astrocytes, although not with memory deficits. PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.