p(HGNC:PRNP)
Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719
Lindquist and colleagues proposed that inhibition of UPS, which can be caused by ageing or following a pharmacological treatment, can lead to accumulation of PrPc in the cytoplasm where it is spontaneously converted into a PrPsc-like species because it is not rapidly degraded by the UPS (Hooper, 2003; Ma and Lindquist,2002;Ma et al., 2002). PubMed:14556719
Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719
Recently, data has shown that injected tau oligomers colocalize with the mitochondrial marker porin, suggesting a pathological relationship PubMed:28420982
Moreover, PrPC inhibits formation fibrillary form of Aβ, trapping Aβ in an oligomeric state (Younan et al. 2013). PubMed:29196815
PrPc is abundant in many cells throughout the body, particularly in the immune and nervous systems, and is typically anchored to the outer cell membrane, where it may act as a copper binding protein with antioxidant properties (Brown,2002). PubMed:14556719
Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719
Recently, data has shown that injected tau oligomers colocalize with the mitochondrial marker porin, suggesting a pathological relationship PubMed:28420982
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.