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Appears in Networks 3

In-Edges 8

bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) View Subject | View Object

Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719

bp(GO:aging) increases p(HGNC:PRNP) View Subject | View Object

Lindquist and colleagues proposed that inhibition of UPS, which can be caused by ageing or following a pharmacological treatment, can lead to accumulation of PrPc in the cytoplasm where it is spontaneously converted into a PrPsc-like species because it is not rapidly degraded by the UPS (Hooper, 2003; Ma and Lindquist,2002;Ma et al., 2002). PubMed:14556719

tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) View Subject | View Object

Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719

a(HBP:"Tau oligomers") association p(HGNC:PRNP) View Subject | View Object

Recently, data has shown that injected tau oligomers colocalize with the mitochondrial marker porin, suggesting a pathological relationship PubMed:28420982

Out-Edges 5

p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") View Subject | View Object

Moreover, PrPC inhibits formation fibrillary form of Aβ, trapping Aβ in an oligomeric state (Younan et al. 2013). PubMed:29196815

p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) View Subject | View Object

PrPc is abundant in many cells throughout the body, particularly in the immune and nervous systems, and is typically anchored to the outer cell membrane, where it may act as a copper binding protein with antioxidant properties (Brown,2002). PubMed:14556719

tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) View Subject | View Object

Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719

p(HGNC:PRNP) association a(HBP:"Tau oligomers") View Subject | View Object

Recently, data has shown that injected tau oligomers colocalize with the mitochondrial marker porin, suggesting a pathological relationship PubMed:28420982

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.