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p(MGI:Dock8)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Dock8
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

bp(GO:"actin cytoskeleton reorganization") positiveCorrelation p(MGI:Dock8) View Subject | View Object

Our finding that DOCK8 is necessary for the cytoskeleton changes and disruption of bacterial phagocytosis by heme is consistent with recent studies showing that DOCK8 regulates dendritic cell migration via Cdc42 (refs. 37,44). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Discussion

bp(MESH:Phagocytosis) negativeCorrelation p(MGI:Dock8) View Subject | View Object

Our finding that DOCK8 is necessary for the cytoskeleton changes and disruption of bacterial phagocytosis by heme is consistent with recent studies showing that DOCK8 regulates dendritic cell migration via Cdc42 (refs. 37,44). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Discussion

complex(a(CHEBI:heme), p(MGI:Dock8)) hasComponent p(MGI:Dock8) View Subject | View Object

Appears in Networks:

p(MGI:Cdc42) positiveCorrelation p(MGI:Dock8) View Subject | View Object

In contrast with wild-type ER-HoxB8 BMDMs, Dock8−/− ER-HoxB8 BMDM did not spread or extend filopodia (Fig. 7a,b), and failed to activate Cdc42 following treatment with heme (Fig. 7c), indicating that DOCK8 was essential for heme-induced activation of Cdc42. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

Out-Edges 3

p(MGI:Dock8) positiveCorrelation p(MGI:Cdc42) View Subject | View Object

In contrast with wild-type ER-HoxB8 BMDMs, Dock8−/− ER-HoxB8 BMDM did not spread or extend filopodia (Fig. 7a,b), and failed to activate Cdc42 following treatment with heme (Fig. 7c), indicating that DOCK8 was essential for heme-induced activation of Cdc42. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

p(MGI:Dock8) positiveCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

Our finding that DOCK8 is necessary for the cytoskeleton changes and disruption of bacterial phagocytosis by heme is consistent with recent studies showing that DOCK8 regulates dendritic cell migration via Cdc42 (refs. 37,44). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Discussion

p(MGI:Dock8) negativeCorrelation bp(MESH:Phagocytosis) View Subject | View Object

Our finding that DOCK8 is necessary for the cytoskeleton changes and disruption of bacterial phagocytosis by heme is consistent with recent studies showing that DOCK8 regulates dendritic cell migration via Cdc42 (refs. 37,44). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.