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PubMed: 24667910

Title
Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage.
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume
34
Issue
None
Pages
1070-5
Date
2014-06-01
Authors
Du H | Gao C | Hua Y | Keep RF | Strahle J | Xi G

Evidence e50e0ebd08
JSON

Coinjection of deferoxamine with lysed RBC reduced ventricular enlargement (47.8±17.8 vs. 59.9±15.7mm3 in saline coinjection group, Po0.05, Figure 6).

a(CHEBI:"desferrioxamine B") negativeCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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Ependyma
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path(MESH:Hydrocephalus) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

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Evidence a0d412bb72
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The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus.

a(CHEBI:"desferrioxamine B") negativeCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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a(HM:"Erythrocytes, lysed") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

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Ependyma
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a(HM:"Erythrocytes, lysed") positiveCorrelation p(PFAM:Ferritin) View Subject | View Object

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Ependyma
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p(PFAM:Ferritin) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

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Ependyma
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path(MESH:Hydrocephalus) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

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Ependyma
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path(MESH:Hydrocephalus) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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Ependyma
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path(MESH:Hydrocephalus) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

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Evidence 7a29b39d7a
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There was a tendency that lysed RBC-induced brain edema was less in deferoxamine-treated group (brain water content in the ipsilateral hemisphere: 79.8±0.6% vs. 80.5±0.7% in the saline coinjection group, n¼6, P40.05).

a(CHEBI:"desferrioxamine B") negativeCorrelation path(MESH:"Brain Edema") View Subject | View Object

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path(MESH:"Brain Edema") negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

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Evidence b2e1900e45
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In addition, iron and ferritin deposition are found in ependymal or subependymal location after neonatal IVH.7–9

a(CHEBI:"iron(2+)") positiveCorrelation path(HP:"Intraventricular hemorrhage") View Subject | View Object

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p(PFAM:Ferritin) positiveCorrelation path(HP:"Intraventricular hemorrhage") View Subject | View Object

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path(HP:"Intraventricular hemorrhage") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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path(HP:"Intraventricular hemorrhage") positiveCorrelation p(PFAM:Ferritin) View Subject | View Object

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Evidence d5cf473cd4
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Twenty-four hours after injection, T2 MRI showed a significant bilateral ventricular enlargement in the iron-injected group (17.9±5.7mm3) compared with salineinjected rats (9.2±5.7mm3, Po0.01, Figure 4).

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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path(MESH:Hydrocephalus) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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Evidence 46e41f3e5e
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Injection of lysed RBCs resulted in significantly larger ventricular volumes (lateral ventricle volume 67.9±10.0mm3) compared with injection of packed RBCs (24.1±6.2mm3, Po0.01) and saline (Po0.01) at 24 hours (Figure 1).

a(HM:"Erythrocytes, lysed") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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Ependyma
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path(MESH:Hydrocephalus) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

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Evidence 336f44d0f3
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There were many more periventricular HO-1-positive cells after injection of lysed RBCs than after saline or packed RBC injection.

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

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Evidence 4aeb2ae6d4
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HO-1 protein levels in the periventricular area were significantly increased in rats receiving lysed RBCs (3,566±2,481 pixels vs. 115±141 pixels in saline group and 295±311 pixels in the packed RBC group, Po0.05, Figure 2).

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

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Evidence 3da53d7909
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There was a marked increase in periventricular ferritin immunoreactivity after injection of lysed RBCs (Figure 3A) compared with saline or packed RBC injection.

a(HM:"Erythrocytes, lysed") positiveCorrelation act(p(PFAM:Ferritin)) View Subject | View Object

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Ependyma
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act(p(PFAM:Ferritin)) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

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Ependyma
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Evidence cff774729c
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Injection of lysed RBCs resulted in higher protein levels of ferritin heavy chain (2,350±429 pixels vs. 800±326 pixels in packed RBC group, Po0.01, Figure 3B) and ferritin light chain (Po0.01, Figure 3C), compared with saline or packed RBCs.

a(HM:"Erythrocytes, lysed") positiveCorrelation p(RGD:Ftl1) View Subject | View Object

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Ependyma
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a(HM:"Erythrocytes, lysed") positiveCorrelation p(RGD:Fth1) View Subject | View Object

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p(RGD:Fth1) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

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Ependyma
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p(RGD:Ftl1) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

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Ependyma
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Evidence c1397b16c1
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Our most recent study has shown that thrombin and thrombin receptor are involved in IVH-induced hydrocephalus.

a(MESH:Thrombin) positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

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path(MESH:Hydrocephalus) positiveCorrelation a(MESH:Thrombin) View Subject | View Object

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