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PubMed: 26751493

Title
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies.
Journal
Biomolecules
Volume
6
Issue
None
Pages
6
Date
2016-01-06
Authors
Babić Leko M | Bažadona D | Buée L | Delalle I | Di Giovanni G | Harrington C | Hof PR | Jovanov-Milošević N | Wischik C | Wray S | de Silva R | Šimić G

Evidence 2803807135
JSON

MB is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler. Moreover, besides its beneficial properties as being able to improve energy metabolism and to act as an antioxidant, it is also able to reduce tau protein aggregation

a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) View Subject | View Object

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a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) View Subject | View Object

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Evidence 7ed5a88805
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The projection domain of tau may be involved in cell signaling that occurs through the interaction with Lck, Fgr and cSrc (Src-family kinases), growth factor receptor-bound protein 2 (Grb2), phospholipase C- [70], phosphatidylinositol and phosphatidylinositol bisphosphate [71,72], peptidyl-prolyl cis/trans isomerase Pin 1, and many others (for review see [73]), making them potential therapeutic targets in tauopathies [74].

a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain") View Subject | View Object

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a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain") View Subject | View Object

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p(FPLX:PLC) association p(HBP:"projection domain") View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:LCK) View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:FGR) View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:SRC) View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:GRB2) View Subject | View Object

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p(HBP:"projection domain") association p(FPLX:PLC) View Subject | View Object

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p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) View Subject | View Object

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p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:PIN1) View Subject | View Object

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p(HGNC:FGR) association p(HBP:"projection domain") View Subject | View Object

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p(HGNC:GRB2) association p(HBP:"projection domain") View Subject | View Object

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p(HGNC:LCK) association p(HBP:"projection domain") View Subject | View Object

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p(HGNC:PIN1) association p(HBP:"projection domain") View Subject | View Object

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p(HGNC:SRC) association p(HBP:"projection domain") View Subject | View Object

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a(CHEBI:"phosphatidylinositol bisphosphate") association a(HBP:"projection domain") View Subject | View Object

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a(CHEBI:phosphatidylinositol) association a(HBP:"projection domain") View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:LCK) View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:FGR) View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:SRC) View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:GRB2) View Subject | View Object

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a(HBP:"projection domain") association p(FPLX:PLC) View Subject | View Object

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a(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) View Subject | View Object

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a(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:PIN1) View Subject | View Object

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p(FPLX:PLC) association a(HBP:"projection domain") View Subject | View Object

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p(HGNC:FGR) association a(HBP:"projection domain") View Subject | View Object

Appears in Networks:

p(HGNC:GRB2) association a(HBP:"projection domain") View Subject | View Object

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p(HGNC:LCK) association a(HBP:"projection domain") View Subject | View Object

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p(HGNC:PIN1) association a(HBP:"projection domain") View Subject | View Object

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p(HGNC:SRC) association a(HBP:"projection domain") View Subject | View Object

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Evidence 90058801dd
JSON

Green coffee, a non-toxic small molecule, found to be an inhibitor of protein phosphatase 2A methylesterase, was shown to improve cognitive and motor performance in mouse models with tau pathology

a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(ECCODE:"3.1.1.89")) View Subject | View Object

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a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") positiveCorrelation act(complex(GO:"respiratory chain complex I")) View Subject | View Object

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act(complex(GO:"respiratory chain complex I")) positiveCorrelation a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") View Subject | View Object

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Evidence e3607587ab
JSON

Other possible inhibitors of tau aggregation are rhodanine-based inhibitors, phenylthiazolyl-hydrazide inhibitors, N-phenylamines, phenothiazines and benzothiazoles, and polyphenols and anthraquinones

a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:emodin) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates") View Subject | View Object

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a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates") View Subject | View Object

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Evidence e2272b4168
JSON

In the case of soluble monomeric or small oligomeric tau protein, the endocytosis appears to be clathrin-dependent (reviewed in [169]). In contrast, larger aggregates of tau could bind heparin in the extracellular matrix and be internalized through macropinocytosis [170]. As a result of exocytosis and endocytosis, the spreading of tau can occur in various neurodegenerative diseases (tauopathies) including AD. Three plausible mechanisms of tau spreading are shown schematically in Figure 6. Additionally, it appea rs that microglial cells may facilitate tau propagation by phagocytosis and exocytosis of tau protein [171].

a(CHEBI:heparin) association p(HBP:"Tau aggregates") View Subject | View Object

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a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) View Subject | View Object

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bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) View Subject | View Object

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bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) View Subject | View Object

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complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) View Subject | View Object

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p(HBP:"Tau aggregates") association a(CHEBI:heparin) View Subject | View Object

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p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) View Subject | View Object

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p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") View Subject | View Object

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Evidence 8f48420908
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A quite different strategy is to target tau clearance—e.g., by rapamycin that induces macroautophagy [175], inhibitors of Hsp90 chaperone protein that binds to misfolded proteins or by immunotherapeutic approaches [176].

a(CHEBI:sirolimus) increases bp(GO:macroautophagy) View Subject | View Object

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bp(GO:macroautophagy) decreases p(HGNC:MAPT) View Subject | View Object

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p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

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Evidence f744c3df66
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In a prospective study three different synaptic protein (synaptophysin, SNAP-25 and syntaxin) were found to be progressively decreased in neocortex at Braak stages III-VI [158], NFT-bearing neurons demonstrating, for example, a 35%–57% reduction in synaptophysin mRNA in AD brain [159].

a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) View Subject | View Object

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a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) View Subject | View Object

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a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) View Subject | View Object

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p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

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p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

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r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

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a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") View Subject | View Object

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p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

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Evidence 9c5619cec8
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The most recent data obtained indicate that tau pathology indeed may be induced and propagated after the injection of tau oligomers or aggregates in either wild-type or mutated MAPT transgenic mice [164], and that tau aggregates can be transferred from cell to cell in vitro [164,165] and in vivo [166,167].

a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) View Subject | View Object

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tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates") View Subject | View Object

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Evidence fa384ad7e8
JSON

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR).

a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:FYN) View Subject | View Object

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p(HBP:"projection domain") association p(HGNC:DLG4) View Subject | View Object

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p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

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p(HGNC:DLG4) association p(HBP:"projection domain") View Subject | View Object

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p(HGNC:FYN) association p(HBP:"projection domain") View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:FYN) View Subject | View Object

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a(HBP:"projection domain") association p(HGNC:DLG4) View Subject | View Object

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a(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

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p(HGNC:FYN) association a(HBP:"projection domain") View Subject | View Object

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p(HGNC:DLG4) association a(HBP:"projection domain") View Subject | View Object

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p(MESH:"Receptors, N-Methyl-D-Aspartate") association a(HBP:"projection domain") View Subject | View Object

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Evidence a932e25429
JSON

An additional “knot” of tau being entangled in epigenetic landscape of neurodegeneration comes from the finding that by acting as a HDAC6 inhibitor, tau is being indirectly involved in both (dys)regulation of transcriptional activity and impairment of autophagic clearance by the ubiquitin proteasome system [81,82].

act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) View Subject | View Object

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p(HGNC:MAPT) decreases act(p(HGNC:HDAC6)) View Subject | View Object

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p(HGNC:MAPT) decreases bp(GO:autophagy) View Subject | View Object

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p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) View Subject | View Object

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Evidence a9d4e49d65
JSON

Recently, it has been proposed that tau protein acetylation may be responsible for tau aggregation in AD. Grinberg and collaborators detected tau acetylation at Lys274 in all tauopathies (both primary and secondary), except in AgD

p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274)) View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates") View Subject | View Object

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Evidence bf04def8d1
JSON

A PSEN1 mutation causes a Pick’s disease phenotype including FTD tau pathology without deposition of Abeta [145]; some MAPT single nucleotide polymorphisms have also been linked to sporadic Parkinson’s disease (PD, [146]);

g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") View Subject | View Object

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g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") View Subject | View Object

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p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") View Subject | View Object

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p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") View Subject | View Object

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p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta") View Subject | View Object

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path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) View Subject | View Object

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path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) View Subject | View Object

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path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738) View Subject | View Object

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path(MESH:"Parkinson Disease") association g(DBSNP:rs242557) View Subject | View Object

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Evidence a3ed983aea
JSON

Apart from binding to MT, the repeat domains of tau also bind to tubulin deacetylase, histone deacetylase 6 (HDAC6) [68] and apolipoprotein E (apoE) more with the

g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") View Subject | View Object

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p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) View Subject | View Object

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p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") View Subject | View Object

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p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") View Subject | View Object

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a(HBP:"microtubule-binding region") association p(HGNC:HDAC6) View Subject | View Object

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p(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") View Subject | View Object

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p(HBP:"tubulin-binding repeat 1") association p(HBP:"APOE e3") View Subject | View Object

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p(HGNC:HDAC6) association a(HBP:"microtubule-binding region") View Subject | View Object

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Evidence b241e7a607
JSON

On the other side, sarkosyl extracts from the filaments of PSP [129], corticobasal degeneration (CBD; [130]), argyrophilic grain disease (AgD; [131]), and some cases of FTDP-17, contain tau protein that separates as doublets of 64 and 69 kDa and are predominantly composed of tau isoforms with 4R (class II tauopathies), whereas sarkosyl extracts from filaments of Pick’s disease are characterized by the presence of pathological tau doublets of 60 and 64 kDa and contain mainly 3R tau isoforms (class III tauopathy).

p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") View Subject | View Object

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p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") View Subject | View Object

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p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease") View Subject | View Object

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p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") View Subject | View Object

Appears in Networks:

path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

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path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

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path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

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path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

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Evidence 910934d579
JSON

The tau fragment first isolated from the PHF core is approximately 100 amino acids in length. Its N-terminus was defined by sequence analysis [30,56], and its C-terminus was defined by epitope mapping of MN423. Immunoreactivity was shown to depend on a specific C-terminal trunctation at Glu391 [33,150].

p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

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p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") View Subject | View Object

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Evidence a75c7a9450
JSON

3. Putative phosphorylation sites on tau protein and epitopes specific for major tau antibodies. Red color denotes amino acids phosphorylation in AD brain.

p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

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Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 68)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 69)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 71)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 113)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 123)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 153)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 175)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 184)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 185)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 191)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 210)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 237)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 238)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 258)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 289)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 403)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 409)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 435)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 427)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 433)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence ea1c8b37f5
JSON

Poorkaj et al. reported two exonic mutations (P301L and V337M) in two families with FTDP-17 [139], while Hutton et al. reported six different mutations in 10 families: three of these mutations (G272V, P301L and R406W) were missense mutations in exons, while the other three were in the 5' splice site of exon 10 [140].

p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") View Subject | View Object

Appears in Networks:

path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) View Subject | View Object

Appears in Networks:

path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) View Subject | View Object

Appears in Networks:

path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) View Subject | View Object

Appears in Networks:

path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.