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PubMed: 28143953

Title
Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model.
Journal
Haematologica
Volume
102
Issue
None
Pages
260-270
Date
2017-02-01
Authors
Lefebvre T | Millot S | Karim Z | Beaumont C | De Verneuil H | Delaby C | Deybach JC | Ducrot N | Ged C | Gouya L | Lettéron P | Lyoumi S | Moulouel B | Pilard N | Puy H | de Franceschi L

Evidence 04f06826eb
JSON

Using isolated duodenal loops to measure the transepithelial iron transport, we found that CEP mice presented a higher rate of iron absorption than the WT mice, although the differences between the area under the curves did not reach statistical significance (Figure 3D).

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Duodenum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Duodenum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence ccd6a861db
JSON

Serum iron was also increased in CEP mice, but this did not lead to elevated Tf saturation because Tf was also significantly increased, which is reminiscent of iron deficiency anemia and facilitates iron delivery to a larger number of erythroblasts (Table 1 and Figure 3G).

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

p(MGI:Trf) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Trf) View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 21b71ddc27
JSON

Iron was also detected in the macrophages of the red pulp of CEP mice, while almost no iron deposit was observed in the spleen of Hjv–/– mice (Figure 4B), confirming that Hb and “free” heme are the likely source of macrophage iron accumulation.

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

a(CHEBI:heme) increases a(CHEBI:"iron(2+)") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

p(HGNC:HBB) increases a(CHEBI:"iron(2+)") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 3abc1315ae
JSON

As expected, Perl’s staining of CEP kidneys showed significant accumulation of iron in the renal cortical part, particularly in the proximal tubules (Figure 6A).

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence a64368df80
JSON

Congenital erythropoietic porphyria mice showed increased serum bilirubin and LDH levels (Table 1), with almost undetectable levels of Hp and Hpx (Figure 1A and B, respectively), which was strongly indicative of hemolytic anemia.

a(CHEBI:bilirubin) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

p(MGI:Hpx) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

p(MGI:Hp) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

p(INTERPRO:"L-lactate dehydrogenase") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:bilirubin) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(INTERPRO:"L-lactate dehydrogenase") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Hpx) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Hp) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

Evidence 9c64d1a5bf
JSON

Type I porphyrins (Uro and Copro) were increased in urine and feces (data not shown) and in RBCs of CEP mice (Table 1).

a(CHEBI:coproporphyrin) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Urine
Text Location
Results

a(CHEBI:uroporphyrin) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Urine
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:uroporphyrin) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Urine
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:coproporphyrin) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Urine
Text Location
Results

Evidence 08fcaf632d
JSON

Indeed, in this organ, there was a strong increase in the total number of erythroblasts at all stages of differentiation (Figure 2C).

a(MESH:Erythroblasts) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(MESH:Erythroblasts) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 70532bf226
JSON

However, in contrast to the bone marrow, there was no significant decrease between intermediate and late erythroblasts (Figure 2C) and we observed decreased rather than increased apoptosis, as usually observed in ineffective erythropoiesis22,23 (Figure 2D).

bp(GO:"apoptotic process") negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence affbe8ae67
JSON

The major regulator of iron homeostasis is hepcidin (reviewed by Ganz1), which is directly down-regulated by stimulated activity of erythropoiesis.2

bp(GO:"iron ion homeostasis") positiveCorrelation p(HGNC:HAMP) View Subject | View Object

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Text Location
Introduction

bp(MESH:Erythropoiesis) decreases p(HGNC:HAMP) View Subject | View Object

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Introduction

p(HGNC:HAMP) positiveCorrelation bp(GO:"iron ion homeostasis") View Subject | View Object

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Introduction

Evidence 91fd4a81f7
JSON

The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1).

bp(MESH:"Erythrocyte Count") negativeCorrelation path(MESH:Anemia) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

p(HGNC:HBB) negativeCorrelation path(MESH:Anemia) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:Anemia) negativeCorrelation p(HGNC:HBB) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:Anemia) negativeCorrelation bp(MESH:"Erythrocyte Count") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 8b779eaaba
JSON

Therefore, hemolytic anemia in CEP mice activates a compensatory stress erythropoiesis with no sign of ineffective erythropoiesis.

bp(MESH:Erythropoiesis) positiveCorrelation path(HP:"Hemolytic anemia") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(HP:"Hemolytic anemia") positiveCorrelation bp(MESH:Erythropoiesis) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence d7c42f212f
JSON

The Hp plasma concentration was very low in CEP mice (Figure 1A), probably because of an increased rate of its endocytosis and subsequent lysosomal degradation.

p(MGI:Hp) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Hp) View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence cbf329bf37
JSON

In addition, we observed an increase of ferroportin protein expression in duodenal enterocytes (Figure 3E and F).

p(MGI:Slc40a1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
bone marrow cell
MeSH
Duodenum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Slc40a1) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
bone marrow cell
MeSH
Duodenum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 41299eb4d1
JSON

In addition, despite an increase in ferritin expression, ferroportin expression was also induced in the liver of CEP mice (Figure 4E), suggesting an increase of iron release in the circulation to satisfy the high iron demand.

p(MGI:Slc40a1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Slc40a1) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 522fc4bf98
JSON

These data suggest that erythrocytes surviving in the circulation are more resistant to in vitro hemolysis: they are likely to correspond to reticulocytes and could explain the increased G6PD activity in CEP erythrocytes (Table 1).

act(p(INTERPRO:"Glucose-6-phosphate dehydrogenase")) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation act(p(INTERPRO:"Glucose-6-phosphate dehydrogenase")) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence ad7949a94e
JSON

We thus analyzed BMP4 expression level in CEP mice and show its strong increase in the red pulp of the spleen (Figure 2E), likely contributing to the rapid formation of stress burst-forming unit erythroid progenitors (BFU-Es) as a consequence of the high levels of erythropoietin (Epo) in these mice (Table 1).

p(MGI:Bmp4) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Bmp4) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence f5235feb6b
JSON

Interestingly, in both liver and spleen, the expression of the Hb-Hp receptor (CD163)29 was found to be fully suppressed at both the mRNA and protein levels (Figure 4C and D and Online Supplementary Figure S1B), suggesting a slowdown of Hb uptake in macrophages which may prevent excess iron overload.

p(MGI:Cd163) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation r(MGI:Cd163) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Cd163) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Cd163) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence ee9d4a0762
JSON

Interestingly, in contrast with the preserved mRNA levels (data not shown), the immunostaining of the endocytic receptor megalin/cubilin complexes revealed evidence of increased cubilin protein expression (Figure 5B) with no significant changes in megalin protein abundance (data not shown).

p(MGI:Cubn) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Cubn) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence aac5b79149
JSON

As expected, serum ferritin was significantly increased in CEP mice (Figure 3H).

p(MGI:Ftl1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Ftl1) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 73ee21d8ad
JSON

Ferritin protein level was significantly increased in the cortex but not in the medulla of CEP mice, confirming exclusive iron handing in the proximal renal tubules in these mice (Figure 6B); no change in the mRNA-expression of ferritin was observed (Figure 6B).

p(MGI:Ftl1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Ftl1) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 91675398d1
JSON

Moreover, HO-1 was highly expressed in the liver of CEP compared to WT mice (Figure 4E), confirming that residual heme uptake is rapidly degraded in the liver.

p(MGI:Hmox1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation p(MGI:Hmox1) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 0d2100655e
JSON

However, the mRNA and protein expression of both TFR1 and DMT1 responsible for iron entry into renal cells were slightly decreased, although not reaching statistical significance (Online Supplementary Figure S4).

p(MGI:Slc11a2) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

p(MGI:Tfrc) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation r(MGI:Tfrc) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation r(MGI:Slc11a2) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Tfrc) View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation p(MGI:Slc11a2) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Slc11a2) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Tfrc) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

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Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 7dde78567f
JSON

As expected, hepcidin was markedly reduced, both in the liver (at the mRNA level) and in the serum (Figure 3A and B).

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation r(MGI:Hamp) View Subject | View Object

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Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Hamp) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 413e2c8968
JSON

Fam132b mRNA expression in bone marrow cells was significantly increased (30-fold compared to WT mice) (Figure 3C).

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation r(MGI:Erfe) View Subject | View Object

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Cell Ontology (CL)
bone marrow cell
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Erfe) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
bone marrow cell
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence f409eaa9d8
JSON

The mRNA level of CD91 was significantly reduced in the liver and was fully suppressed in the spleen (Online Supplementary Figure S1A and B).

path(MESH:"Porphyria, Erythropoietic") negativeCorrelation r(MGI:Lrp1) View Subject | View Object

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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Lrp1) negativeCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
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Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Porphyria, Erythropoietic
Text Location
Results

Evidence 5620bfb52b
JSON

Interestingly, the mRNA expression levels of HO-1 and ferroportin, which are both induced transcriptionally by free heme, were enhanced significantly in the cortex, but not in the medulla, of CEP mice, resulting in large increases in their protein abundance (Figure 6).

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation r(MGI:Ftl1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation r(MGI:Hmox1) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Ftl1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

r(MGI:Hmox1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.