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  3. PubMed:27671637

PubMed: 27671637

Title
Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Volume
113
Issue
None
Pages
11597-11602
Date
2016-10-11
Authors
Anglada-Huguet M | Dennissen FJ | Mandelkow E | Mandelkow EM | Sydow A

Evidence 796b9423df
JSON

64627 treatment improved long-term object recognition memory in proaggregant Tau transgenic mice, as shown by increased novel object preference

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence e2147e06f9
JSON

ATP is reduced in the proaggregant transgenic slices, matching the lower mitochondrial density, compared with littermate controls or antiaggregant Tau transgenic slices (Fig. 3H)

a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion) View Subject | View Object

Appears in Networks:

a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) View Subject | View Object

Appears in Networks:

Evidence fbbebcc476
JSON

Adenosine downmodulates neuronal activity (cFos levels), impairs the presynapse, and attenuates long-term potentiation (LTP) via the A1 receptor (21)

a(CHEBI:adenosine) increases act(p(MGI:Adora1)) View Subject | View Object

Appears in Networks:

a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) View Subject | View Object

Appears in Networks:

a(CHEBI:adenosine) decreases act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:

a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") View Subject | View Object

Appears in Networks:

act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) View Subject | View Object

Appears in Networks:

act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:

act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") View Subject | View Object

Appears in Networks:

Evidence 8ddc8ded41
JSON

We also observed that Tau missorts into a subgroup of proximal dendrites, which correlates with a dramatic spine loss in the affected dendrites (Fig. S2 C and F)

a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Dendrites

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Dendrites

Evidence 462c138f33
JSON

MC-1–positive Tau accumulates in the axonal grains of proaggregant Tau as described above (arrowheads), whereas antiaggregant slices remain unstained

a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

Evidence b8ac31d252
JSON

In organotypic hippocampal slices, both proaggregant and antiaggregant Tau is missorted to the somatodendritic compartment as has been shown before (Fig. 1 A and B, asterisks)

a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Hippocampus

Evidence c8a8857a5c
JSON

When corrected for the difference in total Tau, 12E8 phosphorylation does not differ between proaggregant and antiaggregant Tau (Fig. 2C)

a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") View Subject | View Object

Appears in Networks:

Evidence f10d03c98c
JSON

The antibody AT180 (Tau pThr231) (18) shows (very) weak staining in the cell soma of both types of Tau transgenic slices (Fig. 2 G and H, asterisks) contrasting the high degree of Tau phosphorylated at Ser202/Thr205 [asterisks (somata) and long arrows (apical dendrites)] (AT8 antibody, Fig. 2 I and J)

a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

Appears in Networks:

a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:

Evidence cc02575fb0
JSON

The PHF-1 epitope (pSer396+pSer404, Fig. 2 D–F) is seen in both types of Tau transgenic slices where it appears in the somatodendritic compartment (asterisks) and in the axonal grains (arrowheads)

a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") View Subject | View Object

Appears in Networks:

Evidence 466a435ee8
JSON

Only proaggregant Tau transgenic slices reveal Taupositive beaded structures in the neuropil oriented mostly perpendicular to the apical dendrites of the CA1 pyramidal cells (Fig. 1 C and D, arrowheads) resembling grains in human AGD (16)

a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
pyramidal neuron
MeSH
CA1 Region, Hippocampal

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
pyramidal neuron
MeSH
CA1 Region, Hippocampal

Evidence 43c9e9ba0b
JSON

This suggests that proaggregant Tau accumulates in the axons as grains

a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Axons

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Axons

Evidence cf2118bb42
JSON

Furthermore, we did not see colocalization of the grains of Tau and presynaptic marker synaptophysin (Fig. S3)

a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) View Subject | View Object

Appears in Networks:

Evidence 33f6696b2c
JSON

In line with these observations, the presynaptic impairment in proaggregant Tau transgenic slices can be reversed by 64627 or BSc3094 without causing adverse effects in controls (Fig. 4F and Fig. S6)

a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates") View Subject | View Object

Appears in Networks:

a(MESH:"BSc 3094") increases act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:64627) increases act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:

Evidence 3e2a400ede
JSON

The axons of transfected neurons (Fig. 1 G and I) clearly reveal small inclusions of Tau (∼1 μm in size, arrowheads), although presynaptic boutons (e.g., giant mossy fiber boutons) are only marginally stained for Tau (Fig. 1I and Fig. S2 A and B; arrow), indicating that Tau does not accumulate at presynaptic boutons in these slices

a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) View Subject | View Object

Appears in Networks:

Evidence 726207522b
JSON

Surprisingly, expression of neuronal activity marker cFos, astrocytic activity marker Gfap, and oxidative stress marker Hmox1 were reduced in the proaggregant Tau transgenic slices, whereas antiaggregant Tau transgenic slices were not different from littermate controls (Fig. 4A)

act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

bp(GO:"response to oxidative stress") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) View Subject | View Object

Appears in Networks:

p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) View Subject | View Object

Appears in Networks:

p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") View Subject | View Object

Appears in Networks:

p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") View Subject | View Object

Appears in Networks:

Evidence e576d29c02
JSON

64627 increases neuronal activity (Fos mRNA) both in proaggregant Tau transgenic slices and controls, although in case of the proaggregant slices neuronal activity is almost doubled, yielding levels similar to those of treated littermate control slices (Fig. 4D)

a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:64627) increases act(a(MESH:Neurons)) View Subject | View Object

Appears in Networks:

Evidence bd6cb603d5
JSON

Indeed, the reduced level of spines seen in proaggregant Tau transgenic slices are normalized when treated with 64627, whereas no significant changes are found in antiaggregant Tau transgenic slices or littermate controls (Fig. 5 A and B)

a(PUBCHEM:64627) increases a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:

Evidence f17acc87e9
JSON

The axonal density of mitochondria, which is slightly lower in proaggregant compared with antiaggregant Tau transgenic slices, is marginally decreased by 64627 treatment albeit in a genotype-independent manner (Fig. S7)

a(PUBCHEM:64627) decreases a(MESH:Axons) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 35324a385c
JSON

Surprisingly, the axonal grains of Tau appear to resist protein degradation because they are negative for markers of degradation (vimentin, ubiquitin, Lamp1, Sqstm1/P62, Hsc70, and Tia-1) (Fig. S5)

bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) View Subject | View Object

Appears in Networks:

composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process") View Subject | View Object

Appears in Networks:

Evidence 7e4e50b9bd
JSON

Proaggregant Tau transgenic slices showed a significant reduction of spines compared with littermate control slices, whereas spine density of antiaggregant Tau transgenic slices was similar to controls (Fig. 3 A and B)

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:

Evidence cffa87e85e
JSON

Mitochondria transport is similar in both kinds of Tau transgenic slices (Fig. 3E) with only a moderately lower mitochondrial density in proaggregant Tau transgenic slices compared with antiaggregant slices (Fig. 3F and Table S2)

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) View Subject | View Object

Appears in Networks:

Evidence 93f107af3b
JSON

We observed a typical paired-pulse facilitation (PPF) response in littermate controls and antiaggregant Tau transgenic slices, whereas in proaggregant Tau transgenic slices, the same stimulus paradigm resulted in a paired-pulse depression (Fig. 4B)

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:

Evidence aab1c842dc
JSON

Having observed that 64627 restores presynaptic functioning (i.e., PPF, Fig. 4F), neuronal activity (induction of Fos, Fig. 4D), and dendritic spine levels in proaggregant Tau transgenic organotypic slices (Fig. 5 A and B), we tested whether we could restore long-term spatial memory in proaggregant Tau transgenic mice as well

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 6d39c5f271
JSON

64627 reestablished novel arm preference in proaggregant mice, suggesting that 64627 restores spatial memory in these animals

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 3e3e3e070a
JSON

This result suggests an impaired learning association between the sound and the foot shock in proaggregant mice, which can be rescued by 64627 treatment

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 81d88d6828
JSON

Compared with untreated proaggregant Tau transgenic mice, treated mice (proaggregant Tau transgenics and littermate controls) have significantly larger maximal excitatory postsynaptic potential amplitudes (Fig. 5 G–I)

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 6793cf2e2c
JSON

Treatment with 64627 increases the slope of the I/O curve in both proaggregant Tau transgenic slices and littermate controls (Fig. 5I).

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 2deef30ef4
JSON

By contrast, dendrites that do not contain Tau are richly decorated with spines (>1 spines per μm), indicating that there is only local impairment of dendritic function in case of proaggregant Tau missorting

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Dendrites

Evidence 2f39751200
JSON

We determined mitochondrial movements in live organotypic slices because aggregation-prone Tau is known to impair mitochondrial transport (Fig. 3 D and E)

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") View Subject | View Object

Appears in Networks:

Evidence 236054b27d
JSON

This suggests that the energy status of the neurons is compromised by proaggregant but not by antiaggregant Tau

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons

Evidence 79011c874f
JSON

The slope of the input/output (I/O) curve is significantly reduced in proaggregant Tau transgenic mice compared with controls, indicative of impaired basal synaptic transmission (Fig. 5I)

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Mitochondria

Evidence 236cb8724c
JSON

Phosphorylation of these serines is known to induce detachment of Tau from microtubules and to promote missorting of Tau (17).

p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.